2026 Publications

The virus lesson: Teaching viral structure and quasi-symmetry in mixed reality

Gardner A, Cannac F, Tallon Q, Olson A, Autin L. Protein Sci. 2026 May;35(5):e70570. doi: 10.1002/pro.70570.

PMID: 41972840

PMCID: PMC13073050

Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly

Gupta M, Waltmann C, Renner N, Wang Y, James LC, Jacques DA, Böcking T, Voth GA. Proc Natl Acad Sci U S A. 2026 Mar 17;123(11):e2524995123. doi: 10.1073/pnas.2524995123. Epub 2026 Mar 10.

PMID: 41805577

PMCID: PMC12991430

The host protein cyclophilin A restricts nuclear entry of HIV-1 mutants by reducing the elasticity of the viral capsid

Hong J, Deshpande A, Thakare Y, Simonovsky L, Douglas AW, Guinness CM, Rotem-Dai N, Kortyna ML, Klarhof JO, Shi J, James LC, Boecking T, Francis AC, Rousso I, Aiken C. PLoS Pathog. 2026 Jan 29;22(1):e1013910. doi: 10.1371/journal.ppat.1013910.

PMID: 41610155

PMCID: PMC12871957

Damaging the conical morphology of HIV-1 capsid by targeting the FG-binding pocket and disfavoring pentameric subunits needed for core closure

McFadden WM, Kirby KA, Lorson ZC, Wang L, Highland CM, Harvey SR, Brancato S, Emanuelli Castaner A, Du H, Wysocki VH, Wang Z, Dick RA, Sarafianos SG. bioRxiv [Preprint]. 2026 Mar 20:2026.03.19.712970. doi: 10.64898/2026.03.19.712970.

PMID: 41889801

PMCID: PMC13015717

HIV expression persists in the cerebrospinal fluid of HIV-associated neurocognitive disorders despite effective ART

Prates GS, Li X, Folgosi V, Shabangu CS, Souza GG, Apoliano C, Gascon MR, Monteiro MA, Gualqui C, Santos Eichler R, Gomes H, Katuwal N, Gilbert C, Tang Y, Casseb J, Jiang G. Emerg Microbes Infect. 2026 Dec;15(1):2616945. doi: 10.1080/22221751.2026.2616945. Epub 2026 Feb 3.

PMID: 41527791

PMCID: PMC12872101

Mol*web molecular graphics engine

Rose AS, Tomasello G, Kovács ÁS, Autin L, Sehnal D. Protein Sci. 2026 Apr;35(4):e70514. doi: 10.1002/pro.70514.

PMID: 41820803

PMCID: PMC13032908

MolViewStories: Interactive molecular storytelling

Slanináková T, Charlop-Powers Z, Doshchenko V, Rose AS, Midlik A, Sekuła A, Fonseca N, Morris KL, Burley SK, Velankar S, Fleming J, Vallat B, Autin L, Sehnal D. Protein Sci. 2026 Apr;35(4):e70540. doi: 10.1002/pro.70540.

PMID: 41854287

Predicting water at the protein interface in cryo-EM structures from MD-excess chemical potential

Sun Q, Aiyer S, Biswas A, Haldane A, Chatterjee S, Matubayasi N, Lyumkis D, Levy RM. Biophys J. 2026 Jan 27:S0006-3495(26)00058-5. doi: 10.1016/j.bpj.2026.01.043. Epub ahead of print.

PMID: 41606988

PMCID: PMC13059003

Toward Reconciling the Standard Binding Free Energy of Lenacapavir to HIV-1 Capsid with Experiment: Thermodynamic Effects of Solvent Buffer and Ligand Reorganization

Sun Q, Gallicchio E, Levy R, Deng N. J Phys Chem B. 2026 Feb 19;130(7):2055-2067. doi: 10.1021/acs.jpcb.5c06714. Epub 2026 Feb 10.

PMID: 41665118

PMCID: PMC13081759

Super-Resolution Imaging of Nuclear Pore Responses to Mechanical Stress and Energy Depletion

Torres-Rivera D, Haghparast S, Rieger B, Melikyan GB. Viruses. 2026 Jan 27;18(2):167. doi: 10.3390/v18020167.

PMID: 41754510

PMCID: PMC12945098