2025 Research Highlights

In vivo detection of HIV-1 antisense transcripts in untreated and ART-treated individuals

Capoferri AA, Sklutuis R, Famuyiwa TO, Pathak S, Li R, Rausch JW, Luke BT, Hoh R, Deeks SG, Mellors JW, Coffin JM, Groebner JL, Romerio F, Kearney MF. bioRxiv [Preprint]. 2025 Feb 25:2024.12.06.627170. doi: 10.1101/2024.12.06.627170.

PMID: 40093179

PMCID: PMC11908204

The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir

Huang SW, Briganti L, Annamalai AS, Greenwood J, Shkriabai N, Haney R, Armstrong ML, Wempe MF, Singh SP, Francis AC, Engelman AN, Kvaratskhelia M.  PLoS Pathog. 2025 Jan 27;21(1):e1012862. doi: 10.1371/journal.ppat.1012862.

PMID: 39869652

PMCID: PMC11892807

HIV-1 transcription start sites usage and its impact on unspliced RNA functions in people living with HIV

Islam S, Maldarelli F, Nikolaitchik OA, Cheng Z, Gorelick R, Nikolaitchik MA, Pathak VK, Hu W-S. mBio. 2025 Feb 5;16(2):e0357624. doi: 10.1128/mbio.03576-24. Epub 2024 Dec 27.

PMID: 39727416

PMCID: PMC11796365