2025 Publications
Mechanism of Phosphatidylserine Lipid Scrambling by Human SERINC3, an HIV-1 Restriction Factor
Evolutionary Sequence and Structural Basis for the Epistatic Origins of Drug Resistance in HIV
Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir
PMID: 40231850
PMCID: PMC12077090
In vivo detection of HIV-1 antisense transcripts in untreated and ART-treated individuals
Structural maturation of the matrix lattice is not required for HIV-1 particle infectivity
Elements in the 5′ Untranslated Region of Viral RNA Important for HIV Gag Recognition and Cross-Packaging
MrHAMER2: high-accuracy long-read RNA sequencing to decode isoform-specific variation in viral transcripts during latency
IP6, PF74 affect HIV-1 capsid stability through modulation of hexamer-hexamer tilt angle preference
A monomeric envelope glycoprotein cytoplasmic tail is sufficient for HIV-1 Gag lattice trapping and incorporation
Differential HIV-1 Proviral Defects in Children vs. Adults on Antiretroviral Therapy
Elucidating the mechanism by which HIV-1 nucleocapsid mutations confer resistance to integrase strand transfer inhibitors
The host protein cyclophilin A inhibits HIV-1 nuclear entry by decreasing capsid elasticity
Lenacapavir-induced Lattice Hyperstabilization is Central to HIV-1 Capsid Failure at the Nuclear Pore Complex and in the Cytoplasm
The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir
HIV-1 transcription start sites usage and its impact on unspliced RNA functions in people living with HIV
Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding
PMID: 38328132
PMCID: PMC10849644
Divergent populations of HIV-infected naive and memory CD4+ T cell clones in children on antiretroviral therapy
The central pore of HIV-1 capsomers promotes sustained stability of the viral capsid
Lenacapavir disrupts HIV-1 core integrity while stabilizing the capsid lattice
Phase-separated NDF−FACT condensates facilitate transcription elongation on chromatin
A Hybrid Bottom-Up and Data-Driven Machine Learning Approach for Accurate Coarse-Graining of Large Molecular Complexes
PMID: 40241350
PMCID: PMC12268871
Characterization of antiviral compounds using Bio-Layer Interferometry
Considerations for capsid-targeting antiretrovirals in pre-exposure prophylaxis
Translocation of HIV capsid core through the Nuclear Pore Complex by affinity gradient
How to recover from a bad start: adaptation of HIV-1 transcription start site mutants during serial passaging in culture
Time-Resolved Fluorescence Imaging and Correlative Cryo-Electron Tomography to Study Structural Changes of the HIV‑1 Capsid
PMID: 40844114
PMCID: PMC12409903
Anti-sense oligonucleotide probing as a structural platform for studying ribonucleoprotein complex assembly
Nucleosome Engagement Regulates RORγt Structure and Dynamics
Human RPL7 and DDX21 interact with HTLV-1 Gag and enhance tRNAPro primer annealing to genomic RNA
Persistent type I interferon signaling within the brain of people with HIV on ART with cognitive impairment.
MSBack: Multiscale Backmapping of Highly Coarse-Grained Proteins Using Constrained Diffusion
