2024 Research Highlights

Conformational transitions of the HIV-1 Gag polyprotein upon multimerization and gRNA binding

Computational modeling reveals explores changes in conformation as HIV-1 Gag protein assembles.

Banerjee P, Voth GA. Biophys J. 2024 Jan 2;123(1):42-56. doi: 10.1016/j.bpj.2023.11.017. Epub 2023 Nov 18.

PubMed PMID: 37978800

Elucidating the molecular determinants of the binding modes of a third-generation HIV-1 integrase strand transfer inhibitor: The importance of side chain and solvent reorganization

A novel molecular dynamics method reveals the molecular details of how HIV-1 integrase recognizes strand transfer inhibitors.

Sun Q, Biswas A, Lyumkis D, Levy R, Deng N. Viruses. 2024 Jan 2;16(1):76. doi: 10.3390/v16010076.

PubMed PMID: 38257776