John Briggs, PhD, Director, Max Planck Institute of Biochemistry, Germany, will provide CryoET structural information on capsids within virions, for use in all-atom and coarse grain simulations for Projects 1 and 3.
Alan Rein, Director of the Retroviral Assembly Section, NCI-Frederick, and staff scientist Sid Datta will collaborate on studies of HIV Gag and Gag-Pol polyprotein precursors. Using a defined assembly system that he and his colleagues have developed, Rein and Datta will work with Center investigators to map specific Gag-Gag interactions by HDX and to explore Gag and Gag-Pol interactions in assembly. Their broad expertise in studying retroviral assembly will help to place the Center’s studies of HIV polyproteins in the broader context of HIV assembly and maturation.
Barry Sharpless, PhD, and John Cappiello, PhD, Professor and Staff Scientist, respectively, Scripps Research Institute. They will provide novel SuFEX molecules for targeting capsid and Gag and Gag-Pol polyproteins. Their broad expertise in devising novel SuFEX compounds will complement efforts that will be provided by Core 1.
Davey Smith MD, Director of UC San Diego Center for AIDS Research, will provide resources from the CFAR, including core services in translation virology, bioinformatics and genomics, and protein expression, and as well as clinic investigations. Utilizing the available CFAR Cores will leverage valuable research and clinical services for all Center grant participants.